Blessing Aderibigbe
University of Fort Hare, South Africa
Title: Development, physicochemical and cytotoxic evaluation of polymeric nanocarriers for dual delivery of metal-based anticancer drugs and potentiating agents
Biography
Biography: Blessing Aderibigbe
Abstract
Platinum-based drugs are used for treatment of various types of cancers. However, they suffer from severe limitations such as drug resistance; non-selectivity resulting in severe drug toxicity: nephrotoxicity, neurotoxicity, ototoxicity etc.; short residence time in the central circulation system as a result of rapid excretion and poor water solubility. To improve the therapeutic effects of platinum drugs, they are used in combination with DNA-demethylating agent, incorporated onto drug delivery systems and incorporated onto drug delivery systems together with a potentiating agent that are non-chemotherapeutic agents. In this research polymeric nanocarriers were designed for incorporation of platinum (II) drugs for long term and short term administration. Platinum (II) complex was incorporated onto polymeric nanocarriers together with potentiating agents or DNA-demethylating agent. The physicochemical properties and cytotoxic effects of the nanocarriers were evaluated and the results suggested that the nanocarriers are potential drug delivery systems for combination therapy.