Prashant S Khemariya
SRK Pharmaceutical, India
Title: Formulation of Iron coated Liposomes of SERM and design development of magnetic belt for the management of breast cancer during earlier stages and protection from invasive cancer
Biography
Biography: Prashant S Khemariya
Abstract
Breast cancer remains the utmost common invasive cancer and the second leading cause of cancer mortality for women in the United States. Worldwide, breast cancer comprises 22.9% of all cancers (excluding non-melanoma skin cancers) in the women. It is estimated that globally over 508000 women died in 2011 due to breast cancer (Global Health Estimates, WHO 2013). Liposomes are attractive due to their unique opportunities together with negligible side effects not only in cancer but also in the treatment of other diseases. In this study our aim is to develop combined prospective of Iron coated Liposomes (of Raloxifene Hydrochloride) and design a magnetic belt (magnetism < 0.1 T) for the management of breast cancer during earlier stages and prevention from developing invasive cancer, and osteoporosis in post-menopausal women. Keeping this objective, the present systematic study was focused to design magnetic belt in shape of women’s breast that will contain few magnetic fires having enough magnetism to attract Iron Coated Liposomes only during oral administration of Raloxifene hydrochloride, in order to overcome the poor bioavailability issue with the drug as well. Reloxifene or methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride (a Selective Estrogen Receptor Modulator-SERM) is FDA approved drug and is used to decrease the chance of invasive breast cancer in postmenopausal women who have a high risk for developing the disease or who have osteoporosis. After oral administration of iron loaded liposomes, liposomes will distribute throughout the body through the systemic circulation and while magnetic belt will be on the cancer site (breast) resulting, accumulation of liposomes will be increase on the site because of Iron and magnet intersection. Ultimately drug concentration and absorption will also enhance on the surrounding areas of cancerous cells, hence cancerous cells will be denatured quickly.