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Nada Khudair

Nada Khudair

Qatar University, Qatar

Title: Non-ionic Surfactant Vesicles as Delivery System for Letrozole

Biography

Biography: Nada Khudair

Abstract

Aromatase is an enzyme that leads the bioconversion of androgen into estrogen, which is a main source for cell proliferation and growth in hormone dependent breast cancer. Letrozole (LTZ) is a third generation potent aromatase inhibitor that is approved by the Food and Drug Administration (FDA) for the management of hormone positive breast cancer. The current formulation (Femara®) lacks an effective bioavailability due to LTZ poor-water solubility and rapid systemic metabolism.