Byeongwoon Song
University of California, Davis, USA
Title: Biocompatible Polymeric Assembly as a HIV Drug Delivery System
Biography
Biography: Byeongwoon Song
Abstract
HIV infection and its associated diseases continue to increase despite the progress in our understanding of HIV biology and the availability of a number of antiretroviral drugs. Current HIV treatment regimens require a combination of antiretroviral drugs to be taken at least daily for the remainder of a patient’s life. Adherence remains a significant factor in the success of HIV therapy. A drug delivery system that allows sustained drug release could reduce the medical burden and costs associated with medication non-adherence. Here, we describe a novel supramolecular assembly that contains an anionic polymer hyaluronic acid (HA), cationic polymer poly-L-lysine (PL), and anionic oligosaccharide sulfobutylether-beta-cyclodextrin (SBECD). Physicochemical analysis suggested that HIV reverse transcriptase inhibitors Zidovudine and Lamivudine were successfully encapsulated into an amorphous polymer assembly in a non-covalent manner. Raman microanalysis suggested that the cyclodextrin SBECD contributed to homogeneous incorporation of the antiviral drug into the polymer assembly. Viral inhibition and in vitro drug release studies suggested that the supramolecular assemblies loaded with HIV drugs exhibited potent antiviral activity and maintained sustained drug release. A novel drug delivery formulation described in this study could facilitate our efforts to reduce the morbidity and mortality associated with HIV infections and could be utilized in the design of therapeutic approaches for other human diseases.