Maura Murphy
iCeutica Operations LLC, USA
Title: Bioavailability enhancement using submicron particles
Biography
Biography: Maura Murphy
Abstract
Statement of the Problem: Many compounds exhibit low oral bioavailability due to poor dissolution in-vivo. The poor dissolution is typically due to low water solubility, and improving oral bioavailability of poorly soluble compounds has been a focus of formulation development for many years. Advancements which have been successful include particle size reduction, SEDDS, and amorphous solid dispersions.
Objective: The objectives of this session are to review the current tools available for oral bioavailability enhancement with a focus on particle size reduction, and to introduce a new tool, SoluMatrix Fine Particle Technology™.
Methodology: Drug substance particles can be milled to the submicron size utilizing wet media milling or dry attritor milling. With the dry milling method, the drug substance is milled with excipients and media to produce a free-flowing powder containing submicron particles of the drug substance.
Findings and Conclusions: Multiple case studies demonstrate that submicron particles can improve dissolution and the pharmacokinetics of orally administered poorly soluble drugs. Benefits included increased oral bioavailability, reduction in food effect, more rapid absorption, and thermodynamic stability.