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11th World Drug Delivery Summit

Baltimore, USA

Joël Richard

Joël Richard

IPSEN, France

Title: Delivery of peptides by non-invasive routes: Focus on successful oral technologies progressing in the clinic and future challenges

Biography

Biography: Joël Richard

Abstract

Due to their physicochemical characteristics, peptides are usually administered through the parenteral route, often several times daily. Injectable sustained-release peptide formulations based on biodegradable microparticles or implants have been very successful to enhance patient adherence and convenience, and increase safety and efficacy. They are likely to remain a significant and important part of the new peptide products coming to the market. However, the tremendous developments in alternative non-invasive routes of delivery are likely to result in more and more peptides being delivered by the transdermal, nasal, inhalation and oral routes. The main purpose of this talk will be to analyze and compare the various alternative non-invasive peptide delivery technologies progressing in the clinic, discussing the pros and cons of these technologies in regards to stability, bioavailability, safety/efficacy balance, impact on costs of goods and manufacturability. A special emphasis will be put on oral peptide technologies progressing successfully in the clinic, the key learning from ongoing clinical studies and the future challenges anticipated for filing and launching oral peptide products in the next years.