Julio César Fernández-Travieso
1National Centre for Scientific Research, , Havana, Cuba
Title: A THERAPEUTIC OPTION FOR THE MANAGEMENT OF SYMPTOMS IN PATIENTS WITH OSTEOARTHRITIS
Biography
Biography: Julio César Fernández-Travieso
Abstract
Abstract
Objective: Investigate and demonstrate the benefits of Abexol treatment on symptoms in patients with osteoarthritis.
Methods: Six randomized clinical studies were conducted with Abexol on symptoms in patients with osteoarthritis: two to double blind, placebo controlled six and eight weeks of treatment, one comparative with Lyprinol, another comparative with Prevenox and its combined therapy, and two open, comparative with Chondroitin sulfate/Glucosamine three and six month of treatments. The primary outcome was the reduction of the total WOMAC score. Secondary outcomes included WOMAC pain, stiffness and function scores and VAS score. The reduction of consumption of analgesics was a collateral outcome. In all studies the data were analysed as per the Intention to treat approach.
Results: Abexol treatment produced a documented clinical improvement in patients with osteoarthritis, which was reflected in a significant improvement in pain, stiffness, physical activity and overall symptomatic status, through the total WOMAC score and score of pain of the VAS scale, with an efficacy superior to Lyprinol and comparable to Prevenox and Chondroitin sulfate/Glucosamine. Abexol treatment significantly reduced the consumption of analgesics in these patients. The treatments were safe and well tolerated.
Conclusions: It is concluded that according to the efficacy and safety shown by Abexol in the treatment of patients with osteoarthritis, Abexol could be an alternative for the management of these patients, mainly in those patients who have contraindicated treatment with non-steroidal anti-inflammatories and paracetamol.
Keywords: osteoarthritis symptoms, abexol, lyprinol, chondroitin sulphate/glucosamine, WOMAC score, VAS score.