Yalew Molla
Debre Markos University, Uk
Title: Evaluation of antimalarial activity of the crude extract of stem bark of Combretum molle against Plasmodium berghei in mice
Biography
Biography: Yalew Molla
Abstract
People have a practice of treating malaria using different traditional medicinal plants like Combretum molle without scientific validations. Therefore, the aim of this study was to evaluate the antimalarial activity of the hydroalcoholic stem bark extract of Compertum molle in mice. The mice were randomly divided into five groups (n=5). Group-I mice were treated as negative control and received 3% Tween 80, group-II was treated with 25mg/kg Chloroquine (taken as positive control) and group III, IV & V were treated with 100mg/kg, 200mg/kg and 400mg/kg of the crude extract respectively. Data were analyzed by SPSS version-21 using one-way ANOVA followed by Tukey post hoc analysis. In the chemosuppressive test, the parasitic suppression effect of the crude extract at all doses was found to be significant (P<0.05) as compared to the negative control in a dose dependent pattern. In addition, the 400mg/kg and the 200mg/kg dose of the crude extract had prolonged the survival of mice as compared to the negative control (p<0.05). In the curative test, the average parasitic level of those mice treated by the three doses of the crude extract had been shown to be significantly suppressed at D5, D6 and D7 of treatment as compared to the negative control (p<0.001). The findings of present study had supported the folklore use of the leaves of Combretum molle in the treatment of malaria. Therefore, further fractionation, and characterization of crude extract is necessary to identify the responsible lead compound/s with the potential of antiplasmodial activity.