9^th World Drug Delivery Summit

Biography

Biography: Goldie Oza

Abstract

Encapsulation of High density lipoprotein (HDL) is a novel paradigm which is being explored for Cancer therapeutics. Copper nanoparticles have been emerging as an efficient scaffold for both drug-deliveries as well as for orchestration of HDL, thus mimicking biological vesicles transporting metal complexes. In this reported work, we emphasize specifically on tethering copper nanoparticles with Lapatinib as well as capecitabine drugs since they are combinational therapy for breast cancer. Moreover breast cancer cells undergo aberrant cell proliferation and cholesterol is a known complex playing an important role in cancer cell progression. Hence, HDL has been used for assembling on the surface of copper nanoparticles which are already tethered to anti-cancer drugs. Such HDL nanostructured assembly are known to either target receptor- mediated endocytic holoparticle or scavenger receptors of the B-class. Further to make the complex more synaphic, folate are attached on HDL nanostructured assembly, so that the uptake is further augmented. The mechanism involves selective uptake of HDL-cholesteryl esters - copper nanoparticle- anti-cancer drug complex and then there is subsequent degradation of cholesteryl esters in an extralysosomal compartment which can be mediated by hormone-sensitive lipase. In comparison to natural HDLs, such biomimicked HDL competes with the receptors, thus making cells to be deficient of cholesterol, leading to cellular cholesterol efflux and limited cholesterol delivery. Further, Lapatinib which is a tyrosine kinase inhibitor of human epidermal growth factor receptor typè 2 and epidermal growth factor receptor is very much efficient in regulating the growth of cancer cells in combination with capecitabine. This combinatorial approach of anticancer drug delivery as well as cholesterol starvation selectively induces apoptosis and is an efficient modus operandi for Cancer Therapeutics.