World Drug Delivery Summit August 17-19, 2015 Houston, USA.

Katarzyna Krukiewicz is completing her Ph.D from Silesian University of Technology at the Department of pharmaceutical technology. She has published two papers in reputed journals.

In the past few years local drug delivery systems became very popular methodsrnof treatment, making this process easier and more effective. Since conductingrnpolymers are extensively studied in the field of biosensors, artificial scaffolds andrnneural probes, they are supposed to be promising materials for controlled drugrndelivery systems. Two most popular conducting polymers exhibitingrnbiocompatibility are polypyrrole (PPy) and poly(3,4-ethylenedioxytiophene)rn(PEDOT). Recent literature reports indicate poly(3,4-ethylenedioxypyrrole)rn(PEDOP) as an ideal candidate as material for biomedical engineering, mainlyrnbecause of its biocompatibility. PEDOP combines the most desirable properties ofrnPPy and PEDOT: it has lower polymerization potential than PEDOT and,rnsimultaneously, is more stable than PPy.rnIn this study, we present one of the first efforts to utilize PEDOP for thernimmobilisation of drugs. Two model drugs have been chosen – quercetin (Que)rnand ciprofloxacin (Cipro). Quercetin is one of flavonoid drug with wide spectrum ofrnactivities. Ciprofloxacin mainly treats bacterial infections caused by Gram-positivernand Gram-negative bacteria.

Bradley is in the first year of his PhD at Canterbury University in Christchurch, New Zealand.rnHis project involves numerical modelling of biological processes relating to transdermal drugrndelivery. He is supervised by Dr Sid Becker of the Mechanical Engineering Department. Bradleyrnwas awarded an honours degree from Canterbury University at the end of 2014.

The primary motivation of this study is to develop a macroscopic model of mass transportrnin electroporated biological tissue in order to determine the cellular drug uptake. The modelrncaptures the influences of both irreversible electroporation as well as the transient resealing ofrnthe cell membrane associated with reversible electroporation. The model attempts to fit thernmicroscopic behaviour of the cell membrane to the macroscopic transport characteristics throughrnan empirically based representation of the bulk tissue electrical conductivity. Two case studiesrnare conducted to illustrate the applicability of this model by comparing transport associated withrntwo electrode arrangements: side-by-side arrangement and the clamp arrangement. The resultsrnshow increased drug transmission to viable cells is possible using the clamp arrangement due tornthe more uniform electric field produced.

Jeremy is in the first year of his PhD at Canterbury University in Christchurch, New Zealand.\r\nHis project is in the field of active enhancement methods in transdermal drug delivery. He is\r\nsupervised by Dr Sid Becker of the Mechanical Engineering Department. Jeremy was awarded a\r\nfirst class honours degree from Canterbury University at the end of 2014

This poster outlines the motivations and initial design specifications relating to a custom\r\nexperimental apparatus for sonoporation and sonophoresis experimentation. These experiments\r\nusually involve inserting a cylindrical transducer into a glass Franz diffusion cell. The\r\nmotivations for a custom apparatus are: the hypothesis that the pressure amplitude that is applied\r\nto the current system by the transducer is not equal to the pressure amplitude at a point on the\r\nskin surface due to acoustic reflections in the system (this is supported by preliminary qualitative\r\nresults from a numerical model under development); the ultrasound induced heating within Franz\r\ndiffusion cells that often requires researchers to change experimental fluids mid experiment; and\r\nthe high standard deviations in published results. Some proposed design specifications are: to\r\nmaximize the uniformity of the ultrasound field; to allow for the control of temperature in all\r\nmediums present; to allow for experimental input parameter values at the skin surface to be\r\nmeasured or accurately estimated; and to minimize standard deviation between repetitions\r\n(maximize repeatability). Numerical modelling and 3D printing are both expected to be vital to\r\nthe development of this apparatus. This proposed apparatus is intended to improve the validity\r\nand repeatability of in vitro sonoporation and sonophoresis experiments.

Azadeh Izadyari has completed her master in Chemical Engineering. Currently, she is a doctoral student in Chemical Engineering, University of Ayatollah Amoli Branch. Her thesis is in field of drug delivery and has published many papers in reputed journals. Now, she is working in Pars Azmae Teb(Cerita) as scientific head of southern Iran and Researcher in R&D. Saharnaz Rakizadeh has completed her master in plant biology-Systematics & ecology graduated from University of Tehran, Iran. Now, she is working in research company Pars AzmaeTeb as Science department manager. She has many scientific articles in international authentic scientific journals. Masood Sahraie has completed his PhD in dental science and graduated from University of Shahid Beheshti, Tehran, Iran. Now he is the CEO in Pars Azmaye Teb (Cerita), producing many skin & hair care. Fariba sadat Alambin is Master of science student of Nanobiotechnology in University of Tehran, Iran. She has many papers in international authentic scientific journals. Now, she is working in Pars Azmay Teb (Cerita) as scientific expert.

One of the negative aspects of vitamins is their low absorption through skin. Also, the combination of water or lipo-soluble vitamins and their biological properties protection such as anti-oxidant are difficult for formulating in therapeutic products. Encapsulation of these macromolecules, by liposomal carrier is an important method to preserve their native properties. The aim of this research is producing multi-layer liposomes for encapsulation of vitamins D3, E, A, C and B5 and increasing physical stability of vitamins in therapeutic cream for psoriasis disease treatment. In the current study, liposomes containing vitamins were prepared with thin-film hydration-sonication method. According to FTIR and DSC results, no interaction was observed between encapsulated vitamins and liposome constituents. The particle size and its distribution and encapsulation efficiency were respectively calculated about 250 nm, 0.70–0.85 and more than 92%. Also, liposomes morphology analysis by scanning electron microscopy (SEM) showed spherical form for multi-layer vesicles. Then liposomal carriers were formulated in anti-psoriasis cream to compare its absorption rate and effectiveness with/without encapsulated vitamins. For treated group with liposomal cream, the results showed an increase in its absorption rate through skin (less than 4 minutes) and rapid improvement of lesions (in comparison with cream without vitamin vesicles). So, it can be said the liposomes containing bioactive materials and macromolecules have therapeutic potential applications, improvement of drugs shelf life and its stability in cosmetic products. In this field, physical stability of vitamins in various industry (such as medicine and dermatology) are most important effect of encapsulation method and liposomes as cover, play the great protection role against vitamins degradation.

Vishnu Vardhan Reddy Beeram pursuing PhD from VIGNAN’S University, Vadlamudi, Guntur, Andhrapradesh, India. He has Completed Master of pharmacy in Pharmaceutics \r\nspecialization form Rajiv Gandhi University of Health and Sciences, Bengaluru, Karnataka, India. He has published more than 10 papers in reputed scientific journals.

Novel targeted drug delivery systems have gained attention for the treatment of various chronic diseases with the limitations associated with conventional drug delivery treatment. Among various routes of drug delivery systems, the pulmonary route gained much importance to target drug delivery for both local and systematic treatment. Mostly the treatment efficacy depends on the technique by which the drug is delivered and optimum concentration reached, above or below this level leads to produce toxic or sub therapeutic action. Because of the high permeability and large absorptive surface area of lungs (approx 70-140 m2 in adult humans) and rich blood supply are encouraging or growing interests in developments in pulmonary drug delivery. The smaller airway and alveolar space accounts more than 95% of total lungs surface area and it is directly connected with the systematic circulation via the pulmonary capillary circulation. To deliver drugs into the pulmonary route, the most preferable devices are Dry powder inhalers. Chemotherapy of tuberculosis through inhalable drug delivery system is showing positive approach for eradicating Mycobacterium Tuberculosis by targeting both locally and systematically. This novel approach can maintain the drug concentration above therapeutic and below toxic levels for longer and longer duration with the different formulation development options like controlled or sustained \r\ndrug delivery, mucoadhessive drug delivery. Nanometric range of anti tubercular drug loaded Nanoparticles or Nanospheres with different polymers and combination with any mucoadhessive polymers will offer excellent drug targeting and controlled release for longer duration of time. The drug loaded Nanospheres can make into inhalable dry powder Microparticulates by using inert carriers like mannitol, lactose monohydrate etc. So inhalable drug delivery is increasing interest in chemotherapy of tuberculosis.