Transdermal and Intradermal Drug Delivery
Bio adhesive liposomes contain levonorgestrel as controlled drug delivery system has been investigated. Mesophasic proliposomal system for levonorgestral was processed. The vesicles were predominantly unilamellar and some were multilamellar. Deliver was of zero order kinetics. Alcohol as compared to oils had tremendous influence on transdermal flux. In vivo studies demonstrate that important lag phase was notice before the therapeutic levels were reached reveal the specification for a loading dose. This pro liposomes system was begin to be superior to PEG-based ointment system. Liposomal reservoir system containing local anaesthetic benzocaine was evolved for controlled and localized delivery via topical route. The liposomal suspension was included into an ointment and gel base.
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